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Sclerosing angiomatoid nodular transformation of spleen: a rare case report

Year: 2025

Type: article

Abstract: Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a relatively rare non-neoplastic proliferative mass of vascular origin arising from the red pulp of the spleen accounting for less than 1% of all splenic tumors. Accurate preoperative diagnosis is difficult due to the rarity of the pathology and lack of specific clinical and radiologic features, and final diagnosis of SANT is based on histopathologic and immunohistochemical studies. A 34-year-old male patient who presented with an incidentally found tumor of the spleen discovered on a routine CT examination. The patient underwent classic splenectomy. Pathological examination with immunohistochemical staining confirmed SANT of the spleen. SANT should be included in the differential diagnosis of focal pathology of the spleen due to the rarity of this disease and should be treated by further open or laparoscopic splenectomy with pathologic examination including mandatory immunohistochemical staining.

Source: Perspectives in Surgery

DOI: 10.48095/ccrvch2025543

Authors: Mircea V. Cernat, Lilian F. Antoci, Inga G. Chemencedji, Ala V. Suman, Igor V. Mishin

Institutions: Institutul Oncologic din Republica Moldova, Nicolae Testemițanu State University of Medicine and Pharmacy

Language: English

Topic: Vascular Tumors and Angiosarcomas

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7125599957

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