Work

Innate lymphoid cells as emerging players in cancer immunotherapy

Year: 2026

Type: article

Abstract: With advances in immunology, immune-based approaches to cancer treatment have gradually matured. However, owing to the current limitations of these therapies, there is a need to improve the understanding of the complex immune microenvironment of tumors. Tumor cell progression triggers inflammatory responses coordinated by innate lymphoid cells (ILCs) to regulate tumor cell growth. As tumors evolve and the antitumor immune response proceeds simultaneously, the inherent plasticity and heterogeneity of innate immune cells, which are distinct from adaptive immune cells, can lead to the polarization of innate immune cells in the inflammatory response, ultimately promoting a pro-tumor reaction. In this review, we summarize the characteristics of ILCs and their antitumor and pro-tumor effects, particularly in ongoing and potential therapeutic approaches. Their interactions with adaptive immunity and potential therapeutic approaches are also discussed.

Source: EngMedicine

DOI: 10.1016/j.engmed.2026.100121

Authors: Deyuan Kong, Yun Chen

Institutions: Zhongda Hospital Southeast University, Southeast University, Nanjing Medical University

Language: English

Topic: IL-33, ST2, and ILC Pathways

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,300