Work

Combined Biospectroscopy with Multivariate Analysis for the Differential Diagnosis of Leptospirosis Disease: A Pilot Study

Year: 2026

Type: article

Abstract: -score (0.828), and AUC (0.835), when compared with the results of the preliminary GA-LDA model, and it is possible to rule out the possibility of overfitting of the preliminary GA-LDA model. Suggesting that combined ATR-FTIR spectroscopy with multivariate analysis has great potential to detect biochemical variations produced by the Leptospira pathogen in the blood of infected patients. These findings emerge as a new potential tool for improving leptospirosis diagnosis in the future using a rapid, low-cost, and minimally invasive methodology.

Source: ACS Omega

DOI: 10.1021/acsomega.5c09285

Authors: Alejandra Zambrano, Jorge Trilleras, Victoria Arana Rengifo, Kássio M. G. Lima, Ana Carolina Neves Menezes, Camilo L. M. Morais, Anne B. Figueira Câmara, Roberto Jose García Álzate, Ismael Enrique Piñeres Ariza, Claudia Maria Elisa Romero Vivas, Andrew K. I. Falconar, Margarett Cuello-Pèrez, Carlos Andres Carmona Patiño

Institutions: University of Atlántico, Universidade Federal do Rio Grande do Norte, Universidade Estadual do Ceará, Universidad del Norte

Language: English

Topic: Spectroscopy Techniques in Biomedical and Chemical Research

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,935

Funders: Ministerio de Ciencia, Tecnología e Innovación Productiva, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Universidade Federal do Rio Grande do Norte

Awards: G1834687291, G2981224877, G7982572059

OpenAlex ID: W7125615096

FWCI:

Cites: 47

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