Work

Therapeutic targeting of tumour-associated macrophage receptors.

Year: 2025

Type: review

Abstract: Tumour-associated macrophages (TAM) are present in the majority of tumours, where they comprise one of the most abundant cell types, influencing tumour progression, metastasis, therapy resistance, and relapse. Hence, there is a great interest in targeting TAMs to improve and complement anti-cancer treatments. However, further studies are needed to validate the potential of exploiting TAM cell surface markers for cancer immunotherapy. Here, we review the function of TAMs, their involvement in tumorigenesis, metastasis, and therapy resistance. Furthermore, we summarize the current landscape of key TAM cell surface receptors that are being investigated as potential targets for cancer immunotherapy, highlighting the promise and challenges associated with these approaches.

Source: ePrints Soton (University of Southampton)

Authors: Gomes Alves Martins, Rosa, Tekin, Mehmet Masum, Cragg, Mark, Roghanian, Ali

Institutions: Southampton General Hospital, University of Southampton

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Cancer Research UK, Blood Cancer UK, Directorate for Biological Sciences, Medical Research Council

OpenAlex ID: W7125670623