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Functional Plasticity of Methyltransferases in Anthracycline Biosynthesis: A Single Residue Reversal between Decarboxylation and Hydroxylation

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Year: 2026
Type: article
Source: ACS Catalysis
DOI: 10.1021/acscatal.5c07819
Authors: Moli Sang, Qingyu Yang, Jiawei Guo, Peiyuan Feng, Yu Gao, Wencheng Ma, Shengying Li, Mikko Metsä-Ketelä, Wei Zhang
Institutions: Shandong University, Chinese Academy of Sciences, Institute of Oceanology, Institute of Oceanology, State Key Laboratory of Microbial Technology, University of Turku
Language: English

Topic: Microbial Natural Products and Biosynthesis
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences

Open Access status: closed

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, Shenzhen Fundamental Research Program, Institute of Oceanology, Chinese Academy of Sciences
Awards: G2282970558, G2360648651, G2391032793, G7609076177, G8441976522
OpenAlex ID: W7125677451
FWCI:
Cites: 52
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