Work

The brain side of human-AI interactions in the long-term: the “3R principle”

Year: 2026

Type: article

Abstract: Neuroplasticity is shaped by how humans interact with AI. We argue that passive, uncritical, reliance on AI may weaken activity-dependent brain plasticity and erode cognition, whereas active co-creation can sustain or enhance it. Drawing on plasticity rules and ethical considerations, we propose the 3R principle—Results, Responses, Responsibility—as a preventive framework for cognitive hygiene, urging education towards AI use to preserve agency, meaning-making, and long-term brain health.

Source: npj Artificial Intelligence

DOI: 10.1038/s44387-025-00063-1

Authors: Simone Rossi, Valter Fraccaro, Riccardo Manzotti

Institutions: University of Siena, IULM University

Language: English

Topic: Digital Media and Philosophy

Subfield: Computer Science Applications

Field: Computer Science

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,590

OpenAlex ID: W7125697197