The Synthesis of Tetrakis(N,N-dimethylaminomethyl)ferrocene and Its Bimetallic Nickel(II) Dichloride Complex: The Search for Precursors for Methoxycarbonylation Ligands
Year: 2026
Type: article
Abstract: The family of N,N-dimethylaminomethylferrocene compounds is one of the most important in ferrocene chemistry. They serve as precursors for a range of anti-malarial and anti-tumour medicinal compounds, in addition to being key precursors for ferrocene ligands in the Lucite alpha process. A brief discussion on the importance and synthesis of N,N-dimethylaminomethyl-substituted ferrocenes preludes the synthesis of the new ligand, 1,1′,2,2′-tetrakis-(N,N-dimethylaminomethyl)ferrocene. The crystal structure of this compound is reported, and a comparison is made with its disubstituted analogue, 1,2-bis-(N,N-dimethylaminomethyl)ferrocene. The tetrahedral nickel dichloride complexes of both these ligands have been crystallographically characterised. Finally, a pointer to future research in the area is given, which includes a discussion of a new method to extract ferrocenylmethylamines from mixtures using additives and a new synthetic avenue from substituted cyclopentadiene itself.
Source: Inorganics
Institutions: Bangor University, University of Southampton, Newcastle University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,654
Funder: Bangor University
OpenAlex ID: W7125730756