Work

Patient‐Specific Lumped‐Parameter Model for Quantifying Vessel‐Specific Remodeling and Predicting Right Ventricular Function in Pulmonary Hypertension

Year: 2026

Type: article

Abstract: PURPOSE: Pulmonary hypertension (PH) is a heterogeneous disease with patient-specific variability and vessel-specific remodeling, which eventually lead to right ventricular (RV) failure. The gold standard for RV assessment-pressure-volume (PV) loop acquisition-is invasive and limited to specialized settings. This study aims to develop a patient-specific lumped-parameter model that quantifies vessel-specific remodeling and simulates RV PV loops across PH phenotypes using routine clinical data. METHODS: values for pressure and flow goodness-of-fit, and model-derived hemodynamic metrics were compared with clinical values. A dimensionality reduction approach was applied to investigate how well different PH phenotypes could be separated. RESULTS: Across the cohort, the lumped-parameter model showed good agreement with clinical data. Model-derived vessel-specific (pulmonary arterial, capillary, venular) parameters highlighted physiological distinctions among phenotypes. Predicted RV PV loops revealed phenotype-specific differences in right ventricular volumes, pressures, and stroke work. The linear discriminant analysis (LDA) demonstrated qualitative separability, indicating that model-derived, nonmeasurable features offer additional discriminatory information. CONCLUSION: Our results demonstrate that lumped-parameter models can be calibrated to clinical data to quantify vessel-specific remodeling and simulate RV pressure-volume dynamics to provide useful information for distinguishing among different PH phenotypes. This underscores the potential of computational models as noninvasive, clinically feasible tools for assessing in-depth pulmonary vascular and RV function in PH.

Source: Comprehensive physiology

DOI: 10.1002/cph4.70102

Authors: Christopher G. Lechuga, Amirreza Kachabi, Mitchel J. Colebank, Claudia E. Korcarz, Farhan Raza, Naomi C. Chesler

Institutions: University of California, Irvine, University of South Carolina, University of Wisconsin–Madison

Language: English

Topic: Pulmonary Hypertension Research and Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid