Data from the STEP-HI Randomized Clinical Trial
Year: 2026
Type: dataset
Abstract: This phase 3 double-blind, placebo-controlled randomized clinical trial, Starting a Testosterone and Exercise Program After Hip Injury (STEP-HI), was conducted at 8 US sites between December 2018 and August 2023. Participants were women aged 65 years or older with a recent surgical repair of a nonpathologic femur fracture, met objective criteria for mobility impairment, and were community dwelling after discharge from rehabilitation. During the first 14 months of the trial, participants were randomly assigned to 1 of 3 treatment groups: exercise plus topical testosterone gel, exercise plus placebo gel, or enhanced usual care. Statistical analysis, using a modified intention-to-treat approach, was performed from November 2023 to November 2024.
Source: Mendeley Data
DOI: 10.17632/grgwpgkpdg
Authors: Binder, Ellen F., Bartley, Jenna M., Berry, Sarah D., Doré, Peter M., Fisher, Steven R., Fortinsky, Richard H., Guild, Camelia, Kiel, Douglas P., Kuchel, George A., Marcus, Robin L., McDonough, Christine M., Monroe, Kelly M., Orwig, Denise L., Paluch, Rocco A., Reeds, Dominic, Stevens-Lapsley, Jennifer, Volpi, Elena, Schechtman, Kenneth B., Magaziner, Jay S.
Institutions: Washington University in St. Louis, University of Connecticut, Hebrew SeniorLife, The University of Texas Medical Branch at Galveston, University of Utah, University of Pittsburgh, University of Maryland, Baltimore, University at Buffalo, State University of New York, University of Colorado Anschutz, The University of Texas at San Antonio Health Science Center, University of Maryland School of Medicine
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Institute on Aging
OpenAlex ID: W7125932318
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