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Severe Congenital Neutropenia With Negative Whole-Exome Sequencing Managed With Hematopoietic Stem Cell Transplantation: A Case Report

Year: 2026

Type: article

Abstract: Kostmann syndrome, also known as severe congenital neutropenia, is a congenital disorder characterized by genetic mutations that prevent the progression of myeloid differentiation in the bone marrow. Most cases are associated with specific genetic mutations, including those in HAX1 and ELANE. Treatment with antibiotics and granulocyte colony-stimulating factor (G-CSF) is primarily prophylactic. We report a pediatric case of severe congenital neutropenia present since birth, with negative whole-exome sequencing (WES), complicated by multiple hospital admissions for recurrent infections and subsequent progression to myelodysplastic syndrome with excess blasts associated with monosomy 7, for which the patient ultimately underwent hematopoietic stem cell transplantation (HSCT). This case highlights that many patients with Kostmann syndrome can present with negative genetic testing and draws attention to the importance of surveillance for malignant transformation.

Source: Cureus

DOI: 10.7759/cureus.102496

Authors: Rawia F Albar, Abdulaziz A Abdulaziz, Abdulrahman H Merdad, Badr S Felemban

Institutions: King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, National Guard Health Affairs

Language: English

Topic: Blood disorders and treatments

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7125960605