Work

Acute ketone monoester ingestion increases monocyte lysine β-hydroxybutyrylation and plasma β-hydroxybutyrate amino acid conjugates in humans

Year: 2026

Type: article

Abstract: This study provides the first in vivo evidence that exogenous ketone supplementation elevates lysine Kbhb in monocytes of healthy humans. Exogenous ketone supplementation also increased recently discovered BHB-amino acid conjugates, including BHB-phenylalanine, -leucine, -valine, and -methionine. These results highlight the potential immunomodulatory and systemic signaling effects of exogenous ketones.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00896.2025

Authors: Alexis Marcotte-Chénard, Roderick E. Sandilands, Alexandre Abílio Teixeira, Seth F. McCarthy, Maria Dolores Moya-Garzon, Emily Goldberg, Jonathan Z. Long, Hashim Islam, Jonathan P. Little

Institutions: Université du Québec en Outaouais, University of British Columbia, Okanagan Campus, Stanford Medicine, Stanford University

Language: English

Topic: Diet and metabolism studies

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Michael Smith Health Research BC, Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, Fonds de Recherche du Québec - Santé

Award: Impact of exercise and nutritional manipulations on inflammatory function in humans

OpenAlex ID: W7125963270

FWCI: 8.318

Cites: 22

Cited by: 2

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