Syndrome of inappropriate antidiuresis secondary to multiple myeloma: a case report and literature review
Year: 2026
Type: article
Study design: Case Report
Abstract: The syndrome of inappropriate antidiuresis (SIAD) has been associated with various diseases. However, to our knowledge, only a few studies have reported multiple myeloma (MM) as a potential cause of SIAD. We report a case where hyponatremia served as the primary clinical manifestation, diagnosed with SIAD and subsequently confirmed as multiple myeloma. Following anti-myeloma therapy, the hyponatremia was successfully corrected upon achieving a hematologic response classified as Very Good Partial Response (VGPR). This case contributes to an uncommon etiology of SIAD, highlighting the potential association between SIAD and multiple myeloma, and underscores the need for further research into this connection.
Source: Frontiers in Oncology
Authors: Linling Fan, Ting Ding, Liya Mao, Qian Wang, Hongying Ye, Yiming Li, Shuo Zhang, Lijin Ji
Institutions: Fudan University, Huashan Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: G3259260000, G5761011518
OpenAlex ID: W7125964329