Work

SNX16 functions as a nutrient-sensitive regulator of autophagosomal components recycling

Year: 2026

Type: article

Abstract: In macroautophagy/autophagy, the inner membrane of the autophagosome and its contents are degraded within the autolysosome, while outer membrane proteins are recycled via a process known as autophagosomal components recycling (ACR). ACR is mediated by the recycler complex, powered by dynein-dynactin complexes, and regulated by RAB32-family small GTPases. However, it remains unknown whether ACR is subject to nutrient signal regulation or whether additional molecular components participate in the recycler complex. Our latest research identifies SNX16 as a new component of the recycler complex and reveals that MTORC1 phosphorylates SNX16, enabling SNX16 to function as a nutrient sensor that regulates ACR.

Source: Autophagy

DOI: 10.1080/15548627.2026.2622466

Authors: Huilin Que, Yueguang Rong

Institution: Huazhong University of Science and Technology

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Natural Science Foundation of China

Award: G2713451064