Decoding the lncRNA-miRNA-mRNA network in sepsis-induced lung injury: from pathogenesis to extracellular vesicle-based therapy
Year: 2026
Type: article
Abstract: Sepsis-induced acute lung injury (S-ALI) represents a life-threatening condition with complex molecular pathophysiology and limited therapeutic options. Emerging evidence highlights the critical role of competing endogenous RNA (ceRNA) networks, particularly long non-coding RNA (lncRNA)-microRNA (miRNA)-mRNA axes, in orchestrating cell type-specific responses during S-ALI. This review synthesizes recent advances illustrating how these regulatory circuits modulate alveolar epithelial apoptosis, endothelial permeability, macrophage polarization, and neutrophil infiltration, thereby driving inflammation, barrier dysfunction, and immune dysregulation. Furthermore, we explore the promising therapeutic potential of engineered extracellular vesicles for targeted delivery of ceRNA components-such as miRNA mimics or lncRNA inhibitors-to precisely manipulate these networks. Despite progress, significant challenges remain, including model translatability, functional redundancy, and delivery efficiency. Overcoming these hurdles may unlock novel strategies for treating S-ALI, moving toward personalized and context-specific interventions.
Source: Frontiers in Immunology
Authors: Yating Wei, Weiye Gong, Yuhua Wei, Xiaohong Jiang, Chaoqian Li, Rongzong Ye
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Award: G3810671796
OpenAlex ID: W7125969163