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A PaDd-informed, Assay-calibrated Diagnostic Pathway for Suspected Pulmonary Embolism in Older Adults: From Signal to Strategy

Year: 2026

Type: article

Abstract: To the Editor: We commend Cohen et al. for introducing a prag-matic composite—Padua score × D-dimer (PaDd)—designed to refine pulmonary embolism (PE) exclusion in adults aged ≥65 years, a population often characterized by multimorbidity, physiological heterogeneity, and atypical presentations. Their single-center retrospective cohort (2021–2023) provides a compelling, hypothesis-generating signal: combining a validated venous thromboembolism risk score with D-dimer may enhance specificity without compromising safety.

Source: Rambam Maimonides Medical Journal

DOI: 10.5041/rmmj.10568

Authors: Mulavagili Vijayasimha, Sivaji Adusumalli

Institutions: Chandigarh University, Acharya Nagarjuna University

Language: English

Topic: Venous Thromboembolism Diagnosis and Management

Subfield: Internal Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7125972670