Validation of the MOG-AR Score
Year: 2026
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: A score evaluating age at onset, sex, clinical phenotype, and treatment received (MOG-AR) has been proposed to identify MOGAD patients at high relapse risk. The aim of this study was to validate the MOG-AR score in a multicenter cohort and to assess other variables potentially associated with relapses. METHODS: MOGAD patients were retrospectively enrolled from 24 centers. The MOG-AR score was applied and 4 categories of relapse risk were identified (grade I: lowest risk; grade IV: highest risk), accordingly. The association of MOG-AR score and additional variables with a relapsing course were then explored. RESULTS: Of 190 included patients, the median age at onset was 37 [IQR 23-51] years and 107 (56%) were female. A total of 78 patients (41%) experienced a relapse during a median of 43.6 months [24.8-75.4]. Using the proposed cutoff of 9, the MOG-AR score had a sensitivity of 53.9% [95% CI 55.6-73.9] and a specificity of 65.18% [95% CI 55.60-73.93]; area under the curve: 0.64 (95% CI 0.57-0.72). Among additional investigated factors, only immunosuppressive treatment after the presenting MOGAD attack was associated with a lower relapse risk. DISCUSSION: MOG-AR score failed to accurately predict a relapsing disease course. Only immunosuppressive treatment after the first event was significantly associated with a lower relapse risk.
Authors: Sara Carta, Riccardo Tiberi, Nicola De Rossi, Giorgia Teresa Maniscalco, Giacomo Greco, Antonio Lotti, Alessandro Marziali, Arianna Sartori, Anna Favero, Francesca Rossi, Alessandro Dinoto, Milena Trentinaglia, Vanessa Chiodega, Federica Boso, Silvia Miante, Stefano de Biase, Francesca Caleri, Riccardo Orlandi, Enis Guso, Irene Volonghi, Margherita Nosadini, Stefano Sartori, Pasqualina Palmieri, Alberto Cossu, Francesca Calabria, Pietro Zara, Maria Pia Giannoccaro, Luigi Zuliani, Marika Vianello, Giovanna De Luca, Marco Zoccarato, Anna de Mauro, Luca Massacesi, Rosa Cortese, Alberto Gajofatto, Patrizia Rossi, Elia Sechi, Alberto Vogrig, Valentina Damato, Matteo Gastaldi, Sara Mariotto
Institutions: University of Verona, Marche Polytechnic University, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Ospedale Antonio Cardarelli, University of Florence, University of Udine, Azienda sanitaria universitaria Friuli Centrale, University of Trieste, Ospedale di Cattinara, Provincia Autonoma di Trento, Ospedale dell' Angelo, Krankenhaus Meran, University of Padua, Azienda Ospedale - Università Padova, Azienda Ospedaliera Universitaria Integrata Verona, University of Sassari, Azienda Ospedaliero Universitaria di Sassari, Istituto delle Scienze Neurologiche di Bologna, Azienda ULSS 8 Berica, AULSS 2 Marca Trevigiana, Ospedale SS. Annunziata, University of Siena, Ospedale San Bassiano
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,450
OpenAlex ID: W7125975778