Investigating the Link Between Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists and Non-arteritic Ischemic Optic Neuropathy: A Case Report of Semaglutide-Induced Optic Neuropathy
Year: 2026
Type: article
Study design: Case Report
Abstract: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are newer medications used to treat type 2 diabetes mellitus (T2DM) and obesity. There is growing evidence of a potential association between the use of GLP-1 RAs and non-arteritic anterior ischemic optic neuropathy (NAION). Here, we report a case of NAION in a young patient with diabetes receiving semaglutide (GLP-1 RA), which showed a complete resolution of symptoms after discontinuing the GLP-1 RA. This case adds to growing concerns, given emerging evidence suggesting an increased incidence of NAION among users of GLP-1 RAs. Further studies are required to clarify causality, identify risk factors, and develop monitoring strategies for patients receiving GLP-1 RAs.
Source: Cureus
Authors: Mashair Bakheet, Attiqa Chaudhary
Institutions: Austin Hospital, Austin Health
Language: English
Topic: Drug-Induced Ocular Toxicity
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7125981916