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Exploring the protective mechanisms and therapeutic potential of carnosic acid against acute respiratory distress syndrome through molecular docking, molecular dynamics and experimental verification

Year: 2026

Type: article

Abstract: validation in the murine ARDS model demonstrated that CA treatment effectively mitigated pulmonary pathological damage, suppressed pyroptotic signaling pathways and reduced oxidative stress biomarkers. The present integrative study demonstrated that CA may protect against ARDS by targeting Nrf2, suppressing oxidative stress and pyroptosis. These findings provide a mechanistic understanding of CA and warrant further translational research for clinical application in ARDS management.

Source: Experimental and Therapeutic Medicine

DOI: 10.3892/etm.2026.13077

Authors: Quan Li, Lili Ding, Haijun Sun, Weichao Ding, Mengmeng Wang, Zhaorui Sun, Congxue Ma

Institutions: Nanjing General Hospital of Nanjing Military Command, Nanjing University

Language: English

Topic: Respiratory Support and Mechanisms

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7125982482

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