Work

Adamts5 deletion exacerbates inflammation and fibrosis resulting in compromised skeletal muscle regeneration

Year: 2026

Type: article

Abstract: Glycerol injury to mouse hindlimb muscles results in inefficient regeneration and fibrosis. Adamts5 is a secreted protease, which degrades extracellular matrix (ECM) proteins and has an emerging role in inflammation, fibrosis, and muscle development. In Adamts5-deficient mice, muscle degeneration, inflammation, and fibrosis were increased, and contractile function was impaired for up to 14 days after glycerol injury when compared with wild-type mice. These findings demonstrate the significant role of Adamts5 in muscle regeneration.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00443.2025

Authors: John Dulos, Richard Sun, Valentina Jovanovska, Fabrice Kolb, Nicole Stupka

Institutions: Foundation Centrum '45, The University of Melbourne, Victoria University

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Galápagos