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Decoding atrial mechanics: human atrial slices as a model for atrial disease

Year: 2026

Type: article

Abstract: Human atrial living myocardial slices (LMS) bridge the gap between clinical disease and tissue-level mechanistic insight. Using the largest dataset of human atrial slices to date, this study maps the biomechanical landscape of the atrium and reveals preserved disease-specific signatures in vitro. These findings position LMS as a promising platform for studying atrial pathophysiology and therapeutic development.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00850.2025

Authors: Elisa C. H. van Doorn, Lu Zhang, Kevin M. Veen, Jorik H. Amesz, Jolanda Kluin, Natasja M. S. de Groot, Yannick J. H. J. Taverne

Institution: Erasmus MC

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7125983996

FWCI:

Cites: 61

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