Translating cardiovascular ion channel and Ca 2+ signalling mechanisms into therapeutic insights
Year: 2026
Type: article
Abstract: Cardiovascular diseases remain the leading cause of mortality worldwide, driven by complex, multiscale mechanisms that span molecular, cellular and organ‐level dysfunction. Effective therapeutic strategies therefore require integrative approaches that link fundamental biology to translational applications. The 8 th UC Davis CardioVascular Symposium gathered experts in ion channel biophysics, Ca 2+ signalling, arrhythmia mechanisms and cardiovascular physiology to discuss recent advances and define emerging priorities. This white paper synthesizes the key themes and consensus points that emerged, highlighting progress in two core domains: (1) advances in cardiovascular electrophysiology and arrhythmia mechanisms, and (2) spatiotemporal dynamics of Ca 2+ signalling in cardiac and vascular function and remodelling. We also identify conceptual and technical challenges that must be addressed to accelerate therapeutic discovery and emphasize cross‐cutting opportunities where experimental and computational approaches can converge. By integrating ion channel biology and Ca 2+ signalling mechanisms across scales, this work outlines new directions for advancing cardiovascular research and treatment. image
Source: The Journal of Physiology
DOI: 10.1113/jp290180
Authors: Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi
Institutions: University of Washington, University of California, Davis, Baylor College of Medicine, Montreal Heart Institute, West German Heart and Vascular Center Essen, University of Duisburg-Essen, Université de Montréal, University of Arizona, University of Vermont, University of Maryland, Baltimore, Oslo University Hospital, University of Oslo, Institutt for Eksperimentell Medisinsk Forskning, Masonic Medical Research Laboratory, University of Florida, The Ohio State University Wexner Medical Center, The Ohio State University, University of Virginia
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,400
Awards: G2044093733, Pericytes as metabolic sentinels in the control of brain blood flow in health and Alzheimer's disease, Regeneration-based therapy for the treatment of ventricular tachycardia: a potential alternative to catheter ablation, G2986859818, G3240623501, Investigating sex differences in atrial remodeling and arrhythmia risk in aging, The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis, Systems Approach to Understanding Cardiovascular Disease - Ion channels, Ca2+ regulation and signaling, Investigating atrial remodeling and increased arrhythmia risk in aging, Discovering Lympahtic/Blood Vessel Plasticity In a Novel Tumor Microvascular Environment Model, G8283084991, Brain capillary Piezo1 ion channels and blood flow regulation in Alzheimer’s Disease, G9000023286, G9000056834, G9000267994, A pericyte Cl- clamp controls capillary electrical signaling and brain blood flow, Endothelial Piezo1 channel and cerebral blood flow control, Regulation and dysregulation of sodium channels by by calmodulin, Calmodulin and Regulation of Cardiac Ryanodine Receptor and CaMKII, Pressure Regulation of Vascular CaV1.2 Channels, Flow-Activated Calcium Signaling Microdomains in Small Pulmonary Arteries, Calcium Driven Fibroblast Dysregulation in Human Atrial Profibrotic Remodeling
OpenAlex ID: W7125986511