Work

Atrioventricular area difference assessed by exercise cardiovascular magnetic resonance shows impaired diastolic filling in patients with heart failure

Year: 2026

Type: article

Abstract: Hydraulic force is a newly identified mechanism of diastolic function. This study is the first to assess hydraulic forces in patients with heart failure during exercise using cardiovascular magnetic resonance. In contrast to healthy individuals, hydraulic force decreased from rest to exercise in patients with heart failure, suggesting impaired diastolic filling. These findings offer new mechanistic insights into diastolic dysfunction during exercise and may help explain the hallmark symptom of exercise intolerance in heart failure.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00858.2025

Authors: Jonathan Edlund, Björn Östenson, Julius Åkesson, Einar Heiberg, Håkan Arheden, Katarina Steding-Ehrenborg

Institutions: Lund University, Skåne University Hospital

Language: English

Topic: Cardiovascular Function and Risk Factors

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Hjärt-Lungfonden, Medicinska Fakulteten, Lunds Universitet