Work

Success and Limitations of Current Force Fields for the Description of RNA–Ligand Complexes

Year: 2025

Type: article

Abstract: We present a systematic assessment of the last generation of RNA force fields to reproduce the structures and dynamics of ligand−RNA complexes. Our comprehensive analysis helped not only to define the more reliable force field to represent complex structures but also suggests details that can be improved and provide a critical analysis of the quality of experimental structures in complex systems that are expected to be very flexible and environment dependent.

Source: Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)

Authors: Fernández Migens, Paula, Serrano Chacón, Israel, Orozco López, Modesto, Battistini, Federica

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7126002377

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