Work

Exploring SPARC over Other Exerkines/Myokines: A Strategic Approach Towards Novel Exercise-Mimicking Therapies

Year: 2026

Type: article

Abstract: Identifying novel therapeutic targets for diseases and health conditions represents an important step towards new therapies. Functional genomics and proteomics represent promising tools in identifying such pharmacological targets. Within this context, numerous biomolecules have been characterized as exercise-induced (exerkines) in muscles (myokines). In this article, we present illustrative examples of why secreted protein acidic and rich in cysteine (SPARC) would be a "leading candidate" myokine/exerkine for exploring exercise-induced genes/proteins to develop therapies, clarify mechanisms, and improve various aspects of biomedical research, including population health.

Source: Biomedicines

DOI: 10.3390/biomedicines14020302

Authors: Abdelaziz Ghanemi, Mayumi Yoshioka, Roseane de Fátima Guimarães, Jonny St-Amand

Institutions: University of Victoria, Université Laval, Centre de recherche du CHU de Québec-Université Laval, CHU de Québec-Université Laval, Université du Québec à Trois-Rivières

Language: English

Topic: Exercise and Physiological Responses

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137