Case Report: Recurrent vulvar abscess as the initial manifestation of Crohn’s disease in an adolescent
Year: 2026
Type: article
Study design: Case Report
Abstract: Introduction: Vulvar abscess as the primary and sole manifestation of Crohn's disease (CD) is extremely rare, particularly in adolescents lacking typical gastrointestinal symptoms. This atypical presentation frequently leads to misdiagnosis and delayed treatment. Case description: We report the case of a 16-year-old female admitted for recurrent vulvar abscesses accompanied by high fever. Initial management involved local drainage and antibiotics, but efficacy was limited. Upon admission, targeted history taking revealed a change in bowel habits. Laboratory results indicated a significant inflammatory response and positive fecal calprotectin. Combined with imaging, endoscopy, and pathology, the patient was diagnosed with ileal CD. A multidisciplinary treatment strategy was adopted. This included standardized drainage, necessary antibiotic coverage, and exclusive enteral nutrition (EEN) combined with ustekinumab to achieve steroid-free induction. The patient achieved both clinical and mucosal remission. Conclusion: This case highlights that recurrent vulvar abscesses in adolescents warrant a high index of suspicion for CD. Clinicians must prioritize targeted history taking. Furthermore, fecal calprotectin testing and imaging should be combined to identify potential inflammatory bowel disease (IBD) early, thereby avoiding missed diagnoses and treatment delays.
Source: Frontiers in Medicine
Authors: Ming He, Huimin Ma, Na Huo, Junxia Li, Xiangyan Li
Institutions: Peking University First Hospital, Peking University
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7126034434