Work

Antifungal and molecular analysis of gene expression caused by haloperidol in Candida spp.

Year: 2026

Type: book-review

Abstract: homeostasis, followed by mitochondrial membrane depolarization, reduced ATP production, cytochrome c release into the cytosol and metacaspase activation, reduced viability, phosphatidylserine externalization, promoted fragmentation, damage and methylation of DNA. It also induced expression of genes related to oxidative stress. It reduced mitochondrial depolarization and decreased the reduction of glutathione (GSH), causing morphological alterations. The results suggest the apoptotic pathway as the main antifungal mechanism of haloperidol.

Source: Microbial Pathogenesis

DOI: 10.1016/j.micpath.2026.108343

Authors: Leilson Carvalho de Oliveira, Lara Elloyse de Almeida Moreira, Vitória Pessoa Farias Cabral, Daniel Sampaio Rodrigues, Maria Janielly Castelo Branco Silveira, Thais Lima Ferreira, Ana Carolina Medeiros de Oliveira, Bruno Coêlho Cavalcanti, Islay Lima Magalhães, José Roberto de Oliveira Ferreira, Manoel Odorico de Moares Filho, João Batista de Andrade Neto, Livia Gurgel do Amaral Valente Sá, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva

Institutions: Universidade Federal do Ceará, Unichristus, Universidade Estadual de Ciências da Saúde de Alagoas

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,140

Funders: Secretaría de Educación Superior, Ciencia, Tecnología e Innovación, Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico

OpenAlex ID: W7126052599

Cites: 61

Cited by: 3

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