Work

An Iridium‐Catalyzed Conia‐ene Reaction for the Diastereo‐ and Enantioselective Synthesis of Complex Ring Systems

Year: 2026

Type: article

Abstract: Iridium‐catalyzed Conia‐ene reactions of α‐amino amides are described. These units undergo 6‐ or 7‐ exo cyclization onto amido‐tethered alkenes to provide benzofused N ‐heterocycles. In this process, challenging contiguous stereocenters are installed with high diastereo‐ and enantioselectivity. The method provides a versatile platform for constructing sp 3 ‐rich heterocycles, and offers unusual examples of alkenes engaging in enantio‐ and diastereoselective Conia‐ene reactions. This study adds to an emerging body of processes that exploit the directed generation of Ir‐enolates.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.6718169

Authors: Romi S. Aggarwal, Wenbin Mao, Craig M. Robertson, John F. Bower

Institution: University of Liverpool

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Deutsche Forschungsgemeinschaft, European Research Council

Award: G6736647409