Work

Tauroursodeoxycholic Acid Exerts Neuroprotective Effects in Epilepsy via Suppression of Ferroptosis

Year: 2026

Type: article

Abstract: BACKGROUND: Epilepsy is a complex neurological disorder marked by recurrent, unprovoked seizures. Ferroptosis is characterized by the accumulation of oxidative stress and is associated with the occurrence and development of epilepsy. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has demonstrated neuroprotective properties in various neurodegenerative conditions. In this study, we examined the antiepileptic efficacy of TUDCA and sought to elucidate its underlying mechanisms of action. METHODS: The antiepileptic effects of TUDCA were evaluated using electroencephalogram recordings, behavioral testing, and immunohistochemistry in a Lithium chloride (LiCl)- Pilocarpine (Pilo)-induced epilepsy rat model, alongside a glutamate-induced neuronal cell model. Neuronal ferroptosis was assessed through western blotting and immunofluorescence. RESULTS: , TUDCA similarly exerted neuroprotective effects and effectively suppressed neuronal ferroptosis. CONCLUSION: TUDCA mitigates epilepsy through the suppression of ferroptosis, suggesting its potential as a therapeutic agent for epilepsy treatment.

Source: Journal of Integrative Neuroscience

DOI: 10.31083/jin47186

Authors: Lihui Wang, Yijiao Long, Fei Wang, Jincheng Guo, Lin Li, Baohua Hou

Institution: Henan Polytechnic University

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,900