Teclistamab in Elderly Patients With Relapsed/Refractory Multiple Myeloma: A Subgroup Analysis of the French RetrosTECtive Cohort
Year: 2026
Type: article
Abstract: Introduction: Real-world data on teclistamab in relapsed or refractory multiple myeloma (R/R MM), particularly in elderly patients, remain limited. Methods: cohort. Among 303 patients, 90 were aged ≥ 75 years and compared with 213 younger patients. Results: Elderly patients had fewer high-risk cytogenetic abnormalities and a longer disease history. Remarkably, teclistamab appeared more effective in this population, with 74% achieving at least a very good partial response, compared with 62% of younger patients. Median progression-free survival was 15.1 months in the elderly cohort versus 12.4 months in younger patients. Conclusion: This improved efficacy did not come at the cost of increased toxicity: adverse event rates were comparable, although older patients more frequently received prophylactic measures. These findings support teclistamab as a safe and effective therapeutic option for geriatric patients with R/R MM. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
Source: eJHaem
DOI: 10.1002/jha2.70233
Authors: A. Coste, S. Godet, S. Manier, J. R. Eveillard, C. Croizier, C. Mariette, C. Breal, H. Manjra, C. Touzeau, M. Mohty, R. Belkhir, A. Bobin, A. Lévêque, B. Cherel, L. Montes, F. Orsini‐Piocelle, L. Frenzel, D. Robu, E. Chalayer, S. Harel, L. Vincent, L. Bauschert, A. Dony, R. Tabrizi, P. Moreau, C. Hulin, A. Perrot
Institutions: Centre Hospitalier Universitaire de Reims, Centre Hospitalier Universitaire de Lille, Centre Hospitalier Régional Universitaire de Brest, Centre Hospitalier Universitaire de Clermont-Ferrand, Hôpital Albert Michallon, Centre Hospitalier de Bretagne Sud, Institut Paoli-Calmettes, Centre Hospitalier Universitaire de Nantes, Hôpital Saint-Antoine, Laboratoire d'hématologie, Bicêtre Hospital, Centre Hospitalier Universitaire de Poitiers, Centre hospitalier Bretagne Atlantique, Centre Hospitalier Universitaire Amiens-Picardie, Centre Hospitalier Annecy Genevois, Hôpital Necker-Enfants Malades, Assistance Publique – Hôpitaux de Paris, Centre Hospitalier de Lens, Centre Hospitalier Universitaire de Saint-Étienne, Hôpital Saint-Louis, Hôpital Saint Eloi, Centre Hospitalier Métropole Savoie, Centre Hospitalier Universitaire de Bordeaux
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,860
OpenAlex ID: W7126060212