PTCOG Ocular Survey – Perspective on Ocular Particle Therapy: Current Practices and Emerging Trends
Year: 2026
Type: article
Study design: Observational Study
Abstract: Purpose: To overview the status and trends in the current rapidly evolving field of ocular particle therapy (OPT). Materials and Methods: The Particle Therapy Co-Operative Group Ocular Subcommittee developed an online survey, including 127 questions, made available to treatment centers worldwide, between April 2022 and January 2024. The survey covered a broad range of topics from general program organization and beamline description, to diagnoses and patient numbers treated, treatment planning and set-up, quality assurance techniques, as well as insights into anticipated future developments. Results: Twenty facilities offered OPT by the end of 2023: 3 in Asia, 9 in Europe, and 8 in the USA. Combined, they treated, on average, 1800 patients per year, with uveal melanoma being the most common indication. The vast majority of treatments continue to be delivered on dedicated horizontal beamlines, both high (>120 Mev) and low (<75 MeV) energy. Five of the 7 recently established programs (n = 7, since 2015) use high-energy general-purpose beamlines, where some beam characteristics, including penumbrae size and dose delivery rate, differ from those typically achieved on dedicated beamlines. The evolution of the ocular treatment framework is ongoing as 9 centers reported the intent to upgrade their systems within five years, to engage state-of-the-art developments in beam delivery, imaging, and planning tools. Conclusion: Common protocols in dosimetry, dose, and fractionation have largely been adopted worldwide, while variability persists in planning, quality assurance, and delivery workflows. The obsolescence of dedicated ocular proton systems and key planning tools, and a lack of standardization, remain as pressing challenges. The adoption of non-dedicated high-energy systems on gantries and integration into multipurpose treatment environments enhances OPT accessibility, but this transition requires ongoing critical evaluation of dosimetric trade-offs and clinical outcomes. Multicenter collaboration, technological innovation, and clinical validation are essential to continued assurance of the safe and effective delivery of OPT worldwide.
Authors: Linda Mortimer, Roelf Slopsema, Alejandro Mazal, Jan-Willem Beenakker, Rémi Dendale, Andrea Denker, Emmanuelle Fleury, Anais Groulier, Andrzej Kacperek, Kavita K. Mishra, Jatinder Saini, Alexei V. Trofimov, Juliette Thariat, Petra Trnková, Marie Vidal, Helen A. Shih, Jan Hrbacek, Jens Heufelder
Institutions: Clatterbridge Cancer Centre NHS Foundation Trust, Emory University, IDCQ Hospitales y Sanidad, S.L.U., Leiden University Medical Center, Holland Particle Therapy Center, Institut Curie, Helmholtz-Zentrum Berlin für Materialien und Energie, Erasmus MC, Erasmus MC Cancer Institute, Centre Antoine Lacassagne, University College London, University of California, San Francisco, University of Washington, Massachusetts General Hospital, Mass General Brigham, Centre National de la Recherche Scientifique, École Nationale Supérieure d'Ingénieurs de Caen, Laboratoire de Physique Corpusculaire de Caen, Centre François Baclesse, Institut National de Physique Nucléaire et de Physique des Particules, Université de Caen Normandie, Czech Technical University in Prague, Harvard University, Paul Scherrer Institute, Charité - Universitätsmedizin Berlin
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,700
Funders: Mayo Clinic, Florida Department of Health, Northwestern University, University of Florida, University College London, University College London Hospitals NHS Foundation Trust, National Institutes for Quantum and Radiological Science and Technology, University of California, San Francisco, University of Florida Health
OpenAlex ID: W7126063954