Year: 2026
Type: article
Abstract: Nuclear deformation is a central challenge for migration of cells through confined spaces in the tissue interstitium. In this paper, we review studies on the mechanical roles of the nucleus in confined cell migration. We focus on mechanical force generation by the cytoskeleton on the nuclear surface, the properties of sub-nuclear structures in the process, and functional responses of the nucleus in response to mechanical forces, all in the context of confined cell migration. An emerging theme is that the nucleus acts not only as a barrier for confined migration, but also as a mechanoresponsive organelle whose deformation feeds back to modify cell behaviors. Deciphering these complex processes will be key to understanding how cells navigate complex tissues in development, immunity, and cancer.
Source: Nucleus
Institutions: Texas A&M University, University of Florida
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,993
Awards: Collaborative Research: Biomechanics of Epithelial Tissue Homeostasis, Collapse, and Eversion, Nuclear Dysfunction in Cancer: The Role of Mechanical Stresses Transmittedby the LINC Complex, G5597948186, Collaborative Research: Biomechanics of Epithelial Tissue Homeostasis, Collapse, and Eversion, Collaborative Research: Mechanics of the Topologically Complex Nuclear Envelope, Recruitment of Established Investigators, G9000112816
OpenAlex ID: W7126082421