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Estrogen upregulates NR4A1 to counter TGF beta induced pulmonary fibrosis therapeutic insights for IPF

Year: 2026

Type: article

Abstract: . Overexpression of NR4A1 or inhibition of its phosphorylation attenuated fibrotic responses, whereas NR4A1 deficiency abrogated estrogen's protective effects. These findings elucidate a previously unrecognized mechanism of estrogen-mediated antifibrotic activity and highlight NR4A1 as a promising therapeutic target for IPF.

Source: iScience

DOI: 10.1016/j.isci.2026.114756

Authors: Bao Liu, Haoran Chi, Tingshu Jiang, Xuemei Wang, Fan Cao, Rui Zhang, Zhaihua Liu, Xingang Hu

Institutions: Zhengzhou University, Henan Provincial People's Hospital, China Academy of Chinese Medical Sciences, Yuhuangding Hospital, First Affiliated Hospital of Zhengzhou University

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funder: Henan Provincial People's Hospital

OpenAlex ID: W7126082585

FWCI:

Cites: 40

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