Work

The application of inflammation-modulating dermal scaffolds in chronic wound repair

Year: 2026

Type: article

Abstract: Chronic wounds are a significant global health concern and remain an unresolved challenge. In recent years, with rapid advancements in materials science and the deep integration of biomedicine and materials science, numerous inflammation-modulating dermal substitutes (IMDs) that integrate anti-inflammatory biomaterials and bioactive components have emerged, providing new strategies for the treatment of chronic wounds by precisely regulating the inflammatory microenvironment. This article reviews the roles and mechanisms of actions of IMD scaffolds with varying compositions, physical properties, and drug loadings, focusing on the core pathological mechanism—the imbalanced inflammatory response in chronic wounds. It aims to provide valuable references for researchers and clinicians in related fields and to promote the further development and application of IMD scaffolds.

Source: Materials Today Communications

DOI: 10.1016/j.mtcomm.2026.114757

Authors: Chaoran Xie, Hongchao Huang, Luofeng Jiang, Yongjun Zheng, Zhaofan Xia

Institutions: Second Military Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,830