Work

Netarsudil-associated conjunctival fragility

Year: 2026

Type: article

Abstract: Purpose: To describe six cases of intraoperative and postoperative complications in glaucoma patients with prior or current use of netarsudil. Observation: Patients in this series all had moderate to severe glaucoma and had undergone incisional glaucoma surgery while currently or recently being exposed to netarsudil. Patients had been taking netarsudil in the affected eye for durations ranging from less than one month to six years. Most were on netarsudil within one week of the observed complication. For five patients whose surgery was done at our institution, marked conjunctival fragility was noted intraoperatively. Postoperative complications observed included tube exposures and trabeculectomy bleb leaks in the immediate postoperative period, as well as months to years later. Four of the six patients required surgical revision. Conclusion: Patients with netarsudil exposure may exhibit conjunctival fragility, which can increase the risk of intraoperative and postoperative complications from incisional glaucoma surgery.

Source: American Journal of Ophthalmology Case Reports

DOI: 10.1016/j.ajoc.2026.102533

Authors: Hursuong Vongsachang, Emory Davtyan, Michael M. Lin, Lucy Q. Shen, Milica A. Margeta

Institutions: Massachusetts Eye and Ear Infirmary, Harvard University, Boston University

Language: English

Topic: Glaucoma and retinal disorders

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,590