Adiponectin deficiency drives cerebrovascular dysfunction and synergizes with amyloid-β to exacerbate alzheimer’s pathology
Year: 2026
Type: article
Abstract: Cerebrovascular dysfunction (CVD) is increasingly recognized as a contributor to Alzheimer's disease (AD) progression. Adiponectin (APN), an adipocyte-derived hormone with vasoprotective properties in the periphery, has an unclear impact on AD-related cerebrovascular integrity. We showed that APN-deficient mice exhibited reduced resting cerebral blood flow (CBF), impaired neurovascular coupling (NVC), disrupted blood-brain barrier (BBB), and enhanced cerebral amyloid angiopathy (CAA), which are CVD characteristics that also observed in 5xFAD mice, a model of AD. Notably, APN-deficient 5xFAD mice displayed more severe CVD than 5xFAD mice alone. Transcriptomic analysis of brain endothelial cells (ECs) identified dysregulated biological processes and key signaling pathways underlying EC dysfunction. Importantly, the administration of APN restored CBF and NVC in 5xFAD mice, and prevented tight junction protein (TJP) loss and barrier breakdown in Aβ40-exposed primary ECs. These results highlight the potential of alleviating CVD through targeting ECs with APN as a promising therapeutic strategy to delay the onset and mitigate the progression of AD.
Source: Alzheimer s Research & Therapy
Institutions: University of Hong Kong, Queen Mary Hospital
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,290
OpenAlex ID: W7126110682