Asymmetric Cycloaddition of 1,6-Diynes with Alkenes Enabled by Ligand-to-Metal Chirality Transfer in Cobalt/Photoredox Cooperative Catalysis
Year: 2026
Type: article
Abstract: Here we report a highly enantioselective cycloaddition of 1,6-diynes and alkenes mediated by cobalt/photoredox cooperative catalysis. This transformation requires a chiral monodentate phosphine ligand, which is rarely applied in such reactions because of its limited stereocontrol. DFT studies reveal that the ligand controls metal-centered chirality, enabling the synthesis of multisubstituted cyclohexadienes with excellent enantioselectivity.
Source: Organic Letters
Authors: Takeshi Yasui, Keiji Yamada, Yuki Ishikawa, Kotoko Nakagawa, Rinto Fujii, Yoshihiko Yamamoto
Institution: Nagoya University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7126154341