Work

Breaking the fibrinolytic speed limit with microwheel co-delivery of tissue plasminogen activator and plasminogen

Year: 2026

Type: article

Abstract: Magnetic microswarms were composed of microparticles surface-functionalized with tissue plasminogen activator (tPA) and nanoparticles containing plasminogen, tPA's substrate. A canted rotating magnetic field was used to assemble particles into swarms in situ, then direct their motility to target the site of a model blood clot in vitro. Combined delivery of tPA with its substrate plasminogen enhanced fibrinolysis beyond what was achievable using soluble-phase tPA delivery alone.

Source: Health Research Alliance

DOI: 10.25376/hra.31211782

Authors: Disharoon, Dante, Trewyn, Brian G., Herson, Paco S., Marr, David W.M., Neeves, Keith B.

Language: English

Topic: Micro and Nano Robotics

Subfield: Condensed Matter Physics

Field: Physics and Astronomy

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7126155216

FWCI:

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Related to: 10