Work

RNA-based discovery and correction of splicing defects caused by POLR3A missense mutations

Year: 2026

Type: article

Abstract: missense mutations but also establish CRISPR-dCas13Rx as a useful tool for identifying and correcting disease-causing splicing aberrations.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2026.102850

Authors: Lulzim Shkreta, Aurélie Delannoy, Johanne Toutant, James McSwiggen, Benoit Chabot

Institution: Université de Sherbrooke

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

OpenAlex ID: W7126168443

FWCI: 1.939

Cites: 42

Cited by: 1

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