Acute PGAD-Like Genital Arousal in a 59-Year-Old Woman After Duloxetine Withdrawal: A 36-Month Follow-Up Case Report
Year: 2026
Type: article
Study design: Case Report
Abstract: We report the case of a 59-year-old woman who experienced an acute episode of genital arousal symptoms consistent with Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD), but not fulfilling the duration criterion. The patient had several comorbidities known to be associated risk factors for PGAD/GPD. The most plausible contributing factor was the recent self-initiated cessation of duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI) prescribed for a mixed anxiety-depressive disorder. She was managed with rapid multidisciplinary assessment and short-term intravenous clorazepate and amitriptyline, together with analgesics, while the episode remained self-limited and resolved spontaneously within 5 hours after admission. This case aims to raise awareness among clinicians about acute PGAD-like genital arousal episodes potentially associated with antidepressant withdrawal, the need to carefully review medication histories, and the high level of distress and even suicidality that may accompany these symptoms.
Source: Current Therapeutic Research
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W7126178553