Work

Light focusing through dynamic media via a real-valued intensity transmission matrix

Year: 2026

Type: article

Abstract: Precise light delivery through biological tissue is essential for deep-tissue imaging and phototherapeutic applications. Wavefront shaping enables control over scattered light by modulating the incident wavefront, but its application in living tissue is hindered by tissue-induced temporal decorrelation. This study systematically investigated the real-valued intensity transmission matrix (RVITM), a high-speed wavefront shaping method, for light focusing across a range of speckle decorrelation times (∼10–300 ms). The inherent trade-off between static light focusing enhancement and implementation speed is characterized, providing practical guidelines for implementing RVITM in real-time wavefront shaping under varying dynamic conditions. Effective optical focusing using an RVITM algorithm with a 33 ms runtime was achieved through porcine liver with decorrelation times as short as 13 ms, demonstrating feasibility for biologically relevant dynamics and supporting the development of adaptive, non-invasive optical control for biomedical applications.

Source: Optics Express

DOI: 10.1364/oe.580537

Authors: Xuan Liu, Sebastien Ourselin, Tianrui Zhao

Language: English

Topic: Random lasers and scattering media

Subfield: Acoustics and Ultrasonics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,270

Funders: Royal Academy of Engineering, Engineering and Physical Sciences Research Council

Awards: DTP 2224 King's College London, G5956105215