Relationship between age and severity of cognitive impairment at diagnosis for early‐onset and late‐onset Alzheimer's disease: Comparison of LEADS and ADNI
Year: 2026
Type: article
Abstract: INTRODUCTION: Recent work has identified unique cognitive profiles for early-onset Alzheimer's disease (EOAD) relative to late-onset Alzheimer's disease (LOAD), however, examination has been limited in determining whether the association between age and cognitive severity at presentation also differs across conditions. METHODS: A series of linear spline regression models was conducted across baseline cognitive data from 325 EOAD and 314 LOAD participants, after accounting for education, sex, and apolipoprotein ε4 status. RESULTS: Significant differences existed in the relationship between baseline age and cognitive performance between EOAD and LOAD samples for Processing Speed/Attention, Executive Functioning, and Episodic Immediate Memory. Younger participants from both EOAD and LOAD groups performed disproportionately worse on non-amnestic cognitive domains, with this occurring to a greater extent in EOAD than LOAD. DISCUSSION: In the age of disease-modifying treatments, results highlight the importance of assessing for cognitive declines in individuals starting much earlier than age 65. HIGHLIGHTS: Early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) participants each displayed cognitive impairments relative to same-aged peers across most domains. Both groups displayed positive relationships between impairment among non-amnestic cognitive domains and baseline age. This relationship displayed a significantly greater effect in EOAD than LOAD, with domains of Processing Speed/Attention and Executive Functioning skills being the most pronounced. Of those participants developing AD, age displayed a disproportionate impact on their symptom onset.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.71160
Authors: Dustin B. Hammers, Ani Eloyan, Maryanne Thangarajah, Alexander Taurone, Sujuan Gao, Laurel Beckett, Kala Kirby, Jeffrey L. Dage, Kelly Nudelman, Paul Aisen, Rema Reman, Prashanthi Vemuri, Renaud La Joie, Alexandra Touroutoglou, Alireza Atri, David Clark, Gregory S. Day, Ranjan Duara, Neill R. Graff‐Radford, Lawrence S. Honig, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Kyle Womack, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Ian Grant, Emily Rogalski, Erik C. B. Johnson, Steven Salloway, Sharon J. Sha, Raymond Scott Turner, Thomas S. Wingo, David A. Wolk, Maria C. Carrillo, Bradford C. Dickerson, Gil D. Rabinovici, Liana G. Apostolova, for the Alzheimer's Disease Neuroimaging Initiative
Institutions: Indiana University Indianapolis, Indiana University School of Medicine, Brown University, University of California, Davis, University of Southern California, Mayo Clinic, University of California, San Francisco, Harvard University, Massachusetts General Hospital, Banner Sun Health Research Institute, Mayo Clinic in Florida, Mount Sinai Medical Center, Columbia University Irving Medical Center, Houston Methodist, Weill Cornell Medicine, University of California, Los Angeles, Washington University in St. Louis, Johns Hopkins University, Northwestern University, University of Chicago, Emory University, Stanford University, Georgetown University, University of Pennsylvania, Alzheimer's Association, Alzheimer’s Disease Neuroimaging Initiative
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
Awards: Indiana Alzheimer Disease Center, Early Onset AD Consortium - the LEAD Study (LEADS), 1Florida Alzheimer's Disease Research Center, National Alzheimer's Coordinating Center, Alzheimer's Disease Core Center, Early Onset Alzheimer's Disease Consortium, Stanford Alzheimer's Disease Research Center, The Role of Copy Number Variants and Epigenetic Dysregulation in Early Onset Alzheimer’s Disease (EOAD), Behavioral Interventions for the Treatment of Early Onset AD, Alzheimer's Disease Neuroimaging Initiative, Alzheimer's Disease Research Center - Overall, Indiana University LEADS Diversity Recruitment Supplement, Alzheimer's Disease Research Center, Johns Hopkins Alzheimer's Disease Research Center, Alzheimer's Disease Core Center, Emory Alzheimer's Disease Center, Academic Leadership Award for Statistical Training in Multidisciplinary Aging Research, Behavioral Interventions for the Treatment of Early Onset Alzheimer's Disease, Alzheimer's Disease Neuroimaging Initiative (ADNI4), Indiana Alzheimer's Disease Research Center, New Approaches to Dementia Heterogeneity, National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Massachusetts Alzheimer's Disease Research Center (MADRC), New Approaches to Dementia Heterogeneity
OpenAlex ID: W7126195341