Work

Red herring: Undervirilisation of male foetus due to maternal oestrogen-producing tumour or an intrinsic problem?

Year: 2026

Type: article

Abstract: Disorders of sexual differentiation (DSD) are a cause for significant anxiety. A structured and rapid investigation strategy gives the family solace and the opportunity to institute appropriate therapy. We describe a 46XY undervirilised DSD that was attributed to an estrogen-secreting maternal ovarian cystadenoma tumour. However, diligent and complete workup revealed a different diagnosis altogether. Conservative therapy to support this preterm neonate was first followed; confirmation of the diagnosis helped institute an endocrine consult, anticipatory guidance and regular follow up. Initially apparent causes of DSD must not hamper a detailed algorithmic approach toward a definitive diagnosis.

Source: South Asian Journal of Health Sciences

DOI: 10.25259/sajhs_24_2024

Authors: Zubair Ahmad Bhat, Mohamed Muneer Varikkottil, Femitha Pournami, Naveen Jain

Institution: Kerala Institute of Medical Sciences

Language: English

Topic: Sexual Differentiation and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7126201187