Psychiatric Disorders and Apathy in Mixed Movement Disorders Linked to ADCY5 ( MxMD ‐ ADCY5 )
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Mixed movement disorders linked to ADCY5 (MxMD-ADCY5) represent a rare hyperkinetic movement disorder resulting from pathogenic variants in ADCY5. Psychiatric symptoms are suspected to be part of the phenotype. OBJECTIVE: The study aim was to assess psychiatric comorbidities in patients with MxMD-ADCY5. METHODS: Consecutive patients were assessed with the MINI International Neuropsychiatric Interview (MINI), the shortened Beck Depression Inventory (BDI-13), the Hospital Anxiety and Depression Scale (HADS), and the Starkstein Apathy Scale (SAS). RESULTS: Twenty-seven patients and 20 controls were included. Psychiatric disorders were present in 67% of patients compared with 15% of controls (P = 0.00043), mainly anxiety (33% vs. 0%, P = 0.00862) and depression (44% vs. 10%, P = 0.01068). Depression, anxiety, and apathy scores were higher in patients (BDI-13: 3.67 vs. 1.05, P = 0.004; HA: 6.71 vs. 3.90, P = 0.006; AS: 11.67 vs. 6.85, P = 0.001). CONCLUSION: Depression, anxiety, and apathy are likely part of the phenotypic spectrum of MxMD-ADCY5. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Source: Movement Disorders
DOI: 10.1002/mds.70208
Authors: Aurélie Méneret, Clément Tarrano, Asya Ekmen, Diane Doummar, Victoria Gonzalez, Christine Tranchant, Mathieu Anheim, Philippe Damier, Eoin Mulroy, Kailash P. Bhatia, Laura Cif, Carlo Fusco, Miryam Carecchio, Norbert Brüggemann, Alexander Münchau, Florence Riant, Manon Gomes, Vanessa Brochard, Agathe Roubertie, Oriane Trouillard, Caroline Dubacq, Yulia Worbe, Mohamed Doulazmi, Emmanuel Roze
Institutions: Centre National de la Recherche Scientifique, Inserm, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Institut du Cerveau, Hôpital Saint-Antoine, Hôpital Armand-Trousseau, Vall d'Hebron Hospital Universitari, Institut de génétique et de biologie moléculaire et cellulaire, Hôpitaux Universitaires de Strasbourg, Hôpital d'Hautepierre, Université de Strasbourg, Centre Hospitalier Universitaire de Nantes, Nantes Université, UCL Queen Square Institute of Neurology, University College London, Centre Hospitalier Universitaire Vaudois, Centre Hospitalier Universitaire de Montpellier, Azienda Sanitaria Unità Locale di Reggio Emilia, University of Padua, University Hospital Schleswig-Holstein, University of Lübeck, Institute for Neurosciences of Montpellier
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,480
OpenAlex ID: W7126215895