Work

3D echo derived right ventricular principal surface strain in pulmonary arterial hypertension

Year: 2026

Type: article

Study design: Observational Study

Abstract: Impaired PS Max is associated with worse RV systolic function and outcomes in PAH when compared with conventional 2-D metrics of RV systolic function, while ϴ Max is progressively oriented longitudinally in PAH patients with RH failure compared to those without RH failure, potentially reflecting an echocardiographic representation of maladaptive RV myofiber reorientation. PS Max and ϴ Max represent a powerful and concise way to describe RV systolic function that may prove useful in the care of PAH patients.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00923.2025

Authors: Hannah Takahashi Oakland, Lavanya Bellumkonda, Lissa Sugeng, Phillip Joseph, Priyamvada Kundu, Daniel Izzi, Felica Zalik, Shannon McCabe, Amjad Raza, Ray Amendola, Paul M. Heerdt, Kendall S. Hunter, Inderjit Singh

Institutions: Emory University, Yale University, Medtronic (United States), Yale New Haven Hospital

Language: English

Topic: Cardiovascular Function and Risk Factors

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Yale University, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse

Awards: Cardiorespiratory Pharmacodynamics of Fentanyl-Xylazine, G5634422373, G6918236869, G8391457365, Secondary Analysis of 3D Echo Images of the Right Ventricle to Compute 3D Surface Strain

OpenAlex ID: W7126223650

FWCI: 18.21

Cites: 40

Cited by: 4

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