Work

Shortening antibiotic duration in the treatment of acute cholangitis due to choledocholitiasis with successful biliary duct drainage

Year: 2025

Type: article

Abstract: OBJECTIVE: Aim: To evaluate the efficacy and safety of short duration vs 14-day antibiotic therapy in acute cholangitis associated with common bile duct stone. PATIENTS AND METHODS: Materials and Methods: We divided 278 patients with all stages of acute cholangitis who underwent technically successful ERCP from January 2019 to June 2023 and had positive bile cultures into two groups: antibiotic therapy within two days of ERCP (short-course therapy, SCT; n = 48), and for >3 days (long-course therapy, LCT; n = 230). RESULTS: Results: Three recurrence occurred in STC and one recurrence occurred in LTC (p = 0.19). Clinical outcomes were similar between the two groups. The fever duration was similar between mild and moderate cholangitis within the same group and between the 2 groups. Duration of antibiotic therapy in LTC was 4.22 + 1.37 days with 39 (81.3%) needing treatment for < 5 days. CONCLUSION: Conclusions: Short duration antibiotic treatment based on fever resolution of 72 hours was effective and safe in patients with mild to moderate cholangitis due to common bile duct stone.

Source: Wiadomości Lekarskie

DOI: 10.36740/wlek/210014

Authors: Julia Fuss, Anna Voloboyeva, Valerij Boiko, Viktor Polovyj

Institutions: National Academy of Medical Sciences of Ukraine, Bukovinian State Medical University

Language: English

Topic: Gallbladder and Bile Duct Disorders

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7126236512