Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)
Year: 2026
Type: article
Abstract: Sepsis is a life-threatening clinical syndrome characterized by a dysregulated host immune response to infection, with its pathogenesis closely linked to the aberrant activation and dysfunction of various immune cells.The kidney is among the most vulnerable organs in sepsis.The development of acute kidney injury (AKI) in sepsis, referred to as sepsis-associated AKI (SA-AKI), is often associated with significantly increased mortality.Despite its clinical impact, specific and effective therapies for SA-AKI remain scarce.Increasing evidence highlights that complex intrarenal inflammatory processes, primarily driven by diverse immune cell populations, are central to the onset and progression of SA-AKI.The present review provides a comprehensive analysis of the roles of both innate and adaptive immune cells, such as macrophages, neutrophils, dendritic cells, natural killer cells, natural killer T (NKT) cells, B cells and T cells, in SA-AKI and explores potential therapeutic strategies, offering a theoretical foundation and insights for the development of more effective prevention and treatment approaches.Contents 1. Introduction 2. Role of macrophages in SA-AKI 3. Role of neutrophils in SA-AKI 4. Role of DCs in SA-AKI 5. Role of mast cells in SA-AKI 6. Role of NK cells and NKT cells in SA-AKI 7. Role of ILCs in SA-AKI 8. Role of adaptive immune cells in SA-AKI 9. Potential persistent adverse effects following treatment 10.
Institutions: Northern Jiangsu People's Hospital, Yangzhou University
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7126240209