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Functional characterization of CASP, a CUX1 isoform, reveals its tumor-promoting role in colorectal cancer via TRIM21-mediated signaling

Year: 2026

Type: article

Abstract: mutational profiles. These findings implicate CASP in CRC progression and support its potential as a prognostic biomarker and therapeutic target by disrupting CASP-driven signaling.

Source: iScience

DOI: 10.1016/j.isci.2026.114783

Authors: Biting Zhou, Wangxiong Hu, Wei Dai, Kailun Xu, Lihong Liu, Shu Zheng, Qichun Wei, Ting Chen

Institutions: Second Affiliated Hospital of Zhejiang University, Zhejiang University

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Natural Science Foundation of China, National University's Basic Research Foundation of China, Fundamental Research Funds for the Central Universities

Awards: G257629330, G5570960921, G8749801063

OpenAlex ID: W7126246314

FWCI:

Cites: 31

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