Work

Oxidative stress is exacerbated in the aging cochlea of Alzheimer's disease mouse models

Year: 2023

Type: article

Abstract: Background: Age-related hearing loss (ARHL) is the major risk factor of Alzheimer disease (AD) in midlife. Neuropathogenic interactions between ARHL and AD are unknown. We test the hypothesis that the beta-amyloid proteinopathy linked to AD in the central nervous system has effects on the auditory receptor, which may exacerbate preexisting hearing loss, thus generating an unsuspected vicious circle between ARHL and AD.

Source: RUIdeRA - Institutional University Repository (University of Castilla-La Mancha)

Authors: Juiz Gómez, José Manuel, Alvarado Romero, Juan Carlos, Lenarz, Thomas, Benítez Maican, Zaskya Chiquinquira, Gabladón Ull, María C.

Language: English

Topic: Hearing, Cochlea, Tinnitus, Genetics

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7126747283

FWCI:

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Related to: 10