Work

Suicidal Ideation Following a Single Dose of Melatonin in a Patient With Major Depressive Disorder: A Case Report

Year: 2026

Type: article

Abstract: Melatonin is a neurohormone that primarily regulates sleep patterns and circadian rhythms by interacting with melatonin receptors MT1 and MT2. Disruptions in circadian rhythms may contribute to mood disorders; for example, individuals with major depressive disorder often have significantly lower melatonin levels compared to healthy individuals. In this report, we present a patient who experienced a depressed mood and nighttime sleep disturbances and was treated with melatonin. In patients with depression, factors such as insomnia or poor psychosocial conditions can increase the risk of suicidal thoughts.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.71984

Authors: Rahim Badrfam, Atefeh Zandifar

Institution: Alborz University of Medical Sciences

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820