Work

Vortioxetine in Subgroups of Patients with Major Depressive Disorder and Early-Stage Dementia: Further Results from the MEMORY Study

Year: 2026

Type: article

Abstract: Background: Depression and dementia are common in older adults; however, many antidepressants have limited effectiveness in patients with major depressive disorder (MDD) comorbid with dementia. In the MEMORY study (NCT04294654), significant improvements in depressive symptom severity, cognitive performance, overall functioning, and health-related quality of life were seen in patients with MDD and early-stage dementia during treatment with vortioxetine. This subgroup analysis was undertaken to further explore the effectiveness of vortioxetine in this patient population. Methods: MEMORY was a multinational, open-label, Phase IV study. Patients (n = 82) aged 55– 85 years with MDD and early-stage dementia were treated with vortioxetine (5– 20 mg/day) for 12 weeks. This was a post-hoc analysis for four key subgroups of patients in this study: (i) those with Alzheimer’s disease (n = 35), (ii) those with mixed-type dementia (n = 22), (iii) those receiving concomitant drugs for dementia (n = 34), and (iv) those with severe depression (Montgomery–Åsberg Depression Rating Scale [MADRS] total score ≥ 30) at baseline (n = 42). Results: Significant improvement in depressive symptom severity was seen in all patient subgroups from week 1 onwards ( P < 0.05). At week 12, the mean change from baseline ranged from approximately − 12 to − 14 for MADRS total score ( P < 0.0001), − 6 to − 8 for MADRS anhedonia subscore ( P < 0.0001), and +3 to +6 for Digit Symbol Substitution Test score ( P < 0.05). Improvements in verbal memory, ability to perform activities of daily living, health-related quality of life, and overall disease severity were also observed in all patient subgroups. Conclusion: Our findings provide further support for the effectiveness and tolerability of vortioxetine in patients with MDD and early-stage dementia. Clinically significant improvement in depressive symptoms, cognitive performance, and health-related quality of life during treatment with vortioxetine was observed in patients with Alzheimer’s disease, those with mixed-type dementia, patients receiving concomitant treatment with drugs for dementia, and those with severe depression. Keywords: Alzheimer’s disease, cognitive performance, early-stage dementia, major depressive disorder, mixed-type dementia, vortioxetine

Source: Neuropsychiatric Disease and Treatment

DOI: 10.2147/ndt.s549106

Authors: Iria Grande, Simon Schmidt, Elin Reines, Michael Christensen